产品说明书
Pixantrone
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同义名 : | 匹克生琼来酸盐 ;Pixantrone (maleate);Pixantrone Maleate;BBR 2778 |
| CAS号 : | 144675-97-8 | |
| 货号 : | A387062 | |
| 分子式 : | C25H27N5O10 | |
| 纯度 : | 99%+ | |
| 分子量 : | 557.509 | |
| MDL号 : | MFCD00920108 | |
| 存储条件： |
粉末 Inert atmosphere,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 50 mg/mL(89.68 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 8 mg/mL(14.35 mM)，配合低频超声，并水浴加热至45℃助溶 |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Pixantrone dimaleate induces cell death in various cancer cell lines regardless of cell cycle perturbation, with IC50 values of 37.3 nM, 126 nM, and 136 nM for T47D, MCF-10A, and OVCAR5 cells, respectively, after treatment with concentrations ranging from 0 to 10 μM for 72 hours [1]. Pixantrone dimaleate induces DNA damage at a high concentration of 500 nM after treatment for 24 hours, leading to severe chromosomal aberrations and mitotic catastrophe in PANC1 cells [1]. Pixantrone dimaleate at a concentration of 100 nM for 24 hours may interfere with chromosome segregation by generating merotelic kinetochore attachments, leading to chromosome non-disjunction [1]. Pixantrone dimaleate exhibits potent growth inhibition of human leukemia K562 cells, etoposide-resistant K/VP.5 cells, MDCK, and ABCB1-transfected MDCK/MDR cells, with IC50 values of 0.10 μM, 0.56 μM, 0.058 μM, and 4.5 μM, respectively, after treatment with concentrations ranging from 0 to 100 μM for 72 hours [2]. Pixantrone dimaleate (0.01-0.2 μM) induces the concentration-dependent formation of linear DNA by targeting topoisomerase IIα and generates semiquinone free radicals in an enzymatic reducing system, although not in a cellular system, possibly due to low cellular uptake [2]. Pixantrone dimaleate (0.01-10 μM) exhibits strong inhibitory effects on rat 97-116 peptide-specific T cell proliferation [4]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT01321541 | Diffuse Large B-cell Lymphoma ... 展开 >> de Novo DLBCL DLBCL Transformed From Indolent Lymphoma Follicular Grade 3 Lymphoma 收起 << | Phase 3 | Completed | - | - |
| NCT00069966 | Lymphoma | Phase 2 | Unknown | - | - |
| NCT00551239 | Leukemia Lymp... 展开 >>homa 收起 << | Phase 3 | Unknown | - | United States, Washington ... 展开 >> Cell Therapeutics, Incorporated Seattle, Washington, United States, 98119 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
1.79mL 0.36mL 0.18mL |
8.97mL 1.79mL 0.90mL |
17.94mL 3.59mL 1.79mL |
| 参考文献 |
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