产品说明书
2-Mercaptopyridine N-oxide sodium
 |
同义名 : | 2-巯基吡啶-N-氧化物 钠盐 |
| CAS号 : | 3811-73-2 | |
| 货号 : | A384633 | |
| 分子式 : | C5H4NNaOS | |
| 纯度 : | 96% | |
| 分子量 : | 149.15 | |
| MDL号 : | MFCD01941547 | |
| 存储条件： |
粉末 Inert atmosphere,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
H2O: 100 mg/mL(670.47 mM)，配合低频超声助溶 |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | 2-Mercaptopyridine N-oxide (pyrithione, PTOH) along with several transition metal ions forms coordination compounds displaying notable biological activities. The drug 2-mercaptopyridine-N-oxide (MPNO) inhibits NADH-fumarate reductase purified from T. cruzi (ID50 = 35 microM). When added to intact cells, MPNO inhibited the growth of T. cruzi epimastigotes in culture (ID50 = 0.08 microM) as well as the infection of mammalian myoblasts by T. cruzi trypomastigotes (ID50 = 20 microM). Moreover, MPNO inhibited the accumulation of succinate in cultures of epimastigotes, as measured by high performance liquid chromatography[1]. An organoruthenium(II) complex with pyrithione (2-mercaptopyridine N-oxide) has previously been identified by our group as a compound with promising anticancer potential without cytotoxicity towards non-cancerous cells[2]. A newer agent, 2-mercaptopyridine-N-oxide (Merc) allows us to label leukocytes in plasma, using a simple kit procedure[3]. To obtain a high LE using the lowest possible concentrations of tropolone or merc (2-Mercaptopyridine N-oxide), the granulocytes must be labelled in plasma containing ACD[4]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
6.70mL 1.34mL 0.67mL |
33.52mL 6.70mL 3.35mL |
67.05mL 13.41mL 6.70mL |
| 参考文献 |
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