产品说明书
Apramycin xSulfate
 |
同义名 : | 硫酸安普霉素 ;Nebramycin II sulfate;Ai3-29795 |
| CAS号 : | 65710-07-8 | |
| 货号 : | A382039 | |
| 分子式 : | C21H43N5O15S | |
| 纯度 : | ≥550ug/mg(dried basis) | |
| 分子量 : | 637.656 | |
| MDL号 : | MFCD06200257 | |
| 存储条件： |
粉末 Inert atmosphere,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : |
H2O: 200 mg/mL(313.65 mM) |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Apramycin Sulfate(1:x) is an aminocyclitol aminoglycoside with broad-spectrum in vitro activity against MDR Gram-negative pathogens and Staphylococcus aureus. Apramycin has broad-spectrum, rapidly bactericidal activity against N. gonorrhoeae[3]. Apramycin demonstrated an MIC50/MIC90 of 8/32μg/ml for A. baumannii and 16/32μg/ml for P. aeruginosa. Apramycin appears to offer promising in vitro activity against highly resistant pathogens[4]. Apramycin, an aminocyclitol aminoglycoside, was rapidly bactericidal against Acinetobacter baumannii In a neutropenic murine thigh infection model, treatment-associated A. baumannii CFU reductions of >4 log10 per thigh were observed for all exposures for which area under the curve (AUC)/MIC ratio was >50 and maximum concentration of drug in serum (Cmax)/MIC was ≈10 or higher[5]. Prior to treatment apramycin-resistant Escherichia coli were present but all S. typhimurium isolates were sensitive. Following the treatment of six calves with apramycin, apramycin-resistant S. typhimurium were isolated from two treated calves and one untreated calf[6]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
1.57mL 0.31mL 0.16mL |
7.84mL 1.57mL 0.78mL |
15.68mL 3.14mL 1.57mL |
| 参考文献 |
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