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Pitavastatin lactone

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Chemical Structure| 141750-63-2 同义名 : Pivastatin lactone
CAS号 : 141750-63-2
货号 : A381669
分子式 : C25H22FNO3
纯度 : 99%+
分子量 : 403.445
MDL号 : MFCD09841193
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(260.26 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Pitavastatin lactone is a primary metabolite of Pitavastatin in humans. Pitavastatin serves as a potent competitive inhibitor of HMG-CoA reductase and undergoes minimal metabolism in hepatic microsomes [1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.48mL

0.50mL

0.25mL

12.39mL

2.48mL

1.24mL

24.79mL

4.96mL

2.48mL
参考文献

[1]Fujino H, et al. Metabolic fate of pitavastatin, a new inhibitor of HMG-CoA reductase: human UDP-glucuronosyltransferase enzymes involved in lactonization. Xenobiotica. 2003 Jan;33(1):27-41.