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Sulfabenzamide

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Chemical Structure| 127-71-9 同义名 : 磺胺苯甲酰 ;N-Sulfanilylbenzamide;Sultrin
CAS号 : 127-71-9
货号 : A380447
分子式 : C13H12N2O3S
纯度 : 98%
分子量 : 276.311
MDL号 : MFCD00044890
存储条件：

粉末 Keep in dark place,Inert atmosphere,Room temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(380.01 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Sulfabenzamide is a intermediate in the synthesis of organic and pharmaceutical. Sulfabenzamide metal complexes were active against Gram-positive and negative bacterial strains. Sulfabenzamide complexes exhibited related MIC values from 1.000 to 2.000 g ml-1[1]. Sulfonamide compounds enhanced the avirulent Pseudomonas-induced cell death of Arabidopsis suspension cell cultures and increased disease resistance in Arabidopsis plants against both avirulent and virulent strains of the bacterium. In addition, although sulfonamides are known to be folate biosynthesis inhibitors, the application of folate did not restore the potentiation effects of the sulfonamides on pathogen-induced cell death[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.62mL

0.72mL

0.36mL

18.10mL

3.62mL

1.81mL

36.19mL

7.24mL

3.62mL
参考文献

[1]Rostamizadeh S, Daneshfar Z, Moghimi H. Synthesis of sulfamethoxazole and sulfabenzamide metal complexes; evaluation of their antibacterial activity. Eur J Med Chem. 2019;171:364‐371

[2]Noutoshi Y, Ikeda M, Saito T, Osada H, Shirasu K. Sulfonamides identified as plant immune-priming compounds in high-throughput chemical screening increase disease resistance in Arabidopsis thaliana. Front Plant Sci. 2012;3:245. Published 2012 Oct 31