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Flopropione

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Chemical Structure| 2295-58-1 同义名 : -
CAS号 : 2295-58-1
货号 : A379901
分子式 : C9H10O4
纯度 : 95%
分子量 : 182.173
MDL号 : MFCD00016456
存储条件：

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 145 mg/mL(795.95 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Flopropione is a spasmolytic or antispasmodic agent, and acts as a 5-HT1A receptor antagonist. Flopropione at temperatures below its T(g) shows no Lorentzian relaxation. Flopropione at temperatures below its T(g) has higher molecular mobility than nifedipine[3]. Moreover, Flopropine has been shown to exert a spasmolytic effect not only on smooth muscle of the gastrointestinal tract but also on smooth muscle of the pancreatobiliary and urinary systems[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

5.49mL

1.10mL

0.55mL

27.45mL

5.49mL

2.74mL

54.89mL

10.98mL

5.49mL
参考文献

[1]Bhugra C, Shmeis R, et al. Predictions of onset of crystallization from experimental relaxation times I-correlation of molecular mobility from temperatures above the glass transition to temperatures below the glass transition. Pharm Res. 2006 Oct;23(10):2277-90.

[2]Aso Y, Yoshioka S, et al. Relationship between the crystallization rates of amorphous nifedipine, phenobarbital, and flopropione, and their molecular mobility as measured by their enthalpy relaxation and (1)H NMR relaxation times. J Pharm Sci. 2000 Mar;89(3):408-16.

[3]Aso Y, Yoshioka S, Kojima S. Relationship between the crystallization rates of amorphous nifedipine, phenobarbital, and flopropione, and their molecular mobility as measured by their enthalpy relaxation and (1)H NMR relaxation times. J Pharm Sci. 2000 Mar;89(3):408-16. doi: 10.1002/(SICI)1520-6017(200003)89:3<408::AID-JPS11>3.0.CO;2-#. PMID: 10707020.

[4]Ohgaki K, Horiuchi K, Hikima N, Kondo Y. Facilitation of expulsion of ureteral stones by addition of α1-blockers to conservative therapy. Scand J Urol Nephrol. 2010 Dec;44(6):420-4. doi: 10.3109/00365599.2010.497769. Epub 2010 Jul 7. PMID: 20604720.