产品说明书
Ganoderic acid DM
 |
同义名 : | - |
| CAS号 : | 173075-45-1 | |
| 货号 : | A379417 | |
| 分子式 : | C30H44O4 | |
| 纯度 : | 98+% | |
| 分子量 : | 468.668 | |
| MDL号 : | MFCD04039843 | |
| 存储条件： |
粉末 液体 -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : |
DMSO: 50 mg/mL(106.69 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
|
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Ganoderic acid DM, a natural product isolated and purified from the fruit body of Ganoderma lucida, effectively inhibits cell proliferation and colony formation in MCF-7 human breast cancer cells, which is much stronger than that of MDA-MB-231 breast cancer cells, and is also an antiandrogenic osteoclastogenesis inhibitor. Ganoderic acid DM especially suppresses the expression of c-Fos and nuclear factor of activated T cells c1 (NFATc1), this suppression leads to the inhibition of dendritic cell-specific transmembrane protein (DC-STAMP) expression and reduces osteoclast fusion, and has shown toxicity to both androgen-dependent and independent prostate cancer cells with reduced osteoclastogenesis in late stage metastatic disease, it may an alternative agent for the treatment of advanced prostate cancer. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
2.13mL 0.43mL 0.21mL |
10.67mL 2.13mL 1.07mL |
21.34mL 4.27mL 2.13mL |
| 参考文献 |
|---|