产品说明书

CCG-63802

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Chemical Structure| 620112-78-9 同义名 : -
CAS号 : 620112-78-9
货号 : A379059
分子式 : C26H18N4O2S
纯度 : 98+%
分子量 : 450.512
MDL号 : MFCD04190628
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 1.5 mg/mL(3.33 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 CCG-63802 is a reversible inhibitor of regulator of G-protein signaling (RGS) protein with greatest potency at RGS4.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.22mL

0.44mL

0.22mL

11.10mL

2.22mL

1.11mL

22.20mL

4.44mL

2.22mL
参考文献

[1]Bosier B, Doyen PJ, et al. Inhibition of the regulator of G protein signalling RGS4 in the spinal cord decreases neuropathic hyperalgesia and restores cannabinoid CB1 receptor signalling. Br J Pharmacol. 2015 Nov;172(22):5333-46.

[2]Blazer LL, Roman DL, et al. Reversible, allosteric small-molecule inhibitors of regulator of G protein signaling proteins. Mol Pharmacol. 2010 Sep;78(3):524-33.