8-Azaguanine
产品说明书
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同义名 : | 8-氮鸟嘌呤 ;NSC-749;SF-337;B-28;AZG;AI3-25015;8 AG;Azaguanine;SK 1150;Azaguanine-8 |
| CAS号 : | 134-58-7 | |
| 货号 : | A378059 | |
| 分子式 : | C4H4N6O | |
| 纯度 : | 95% | |
| 分子量 : | 152.114 | |
| MDL号 : | MFCD00056937 | |
| 存储条件： |
Pure form Keep in dark place,Inert atmosphere,Store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 2 mg/mL(13.15 mM)，配合低频超声，水浴加热至45℃，并调节pH至5，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
IP 2% DMSO+water 0.06 mg/mL clear PO 0.5% CMC-Na 56 mg/mL suspension |
| 生物活性 | |||
|---|---|---|---|
| 描述 | 8-Azaguanine, a purine analog, exhibits antineoplastic activity by functioning as an antimetabolite that integrates into ribonucleic acids, disrupting normal biosynthetic pathways and inhibiting cellular growth[1]. | ||
| 细胞研究 | |||||
|---|---|---|---|---|---|
| 细胞系 | 浓度 | 检测类型 | 检测时间 | 活动说明 | 数据源 |
| H.Ep cells | Cytotoxicity assay | Cytotoxicity against H.Ep cells, IC50=2 μM | 6620307 | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
6.57mL 1.31mL 0.66mL |
32.87mL 6.57mL 3.29mL |
65.74mL 13.15mL 6.57mL |
| 参考文献 |
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