产品说明书

Alovudine

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Chemical Structure| 25526-93-6 同义名 : 阿洛夫定（3'-脱氧-3'-氟胸苷） ;3'-Fluoro-3'-deoxythymidine;3′-Deoxy-3′-fluorothymidine;NSC 140025;MIV-310;FddThd;CL 184824;FLT
CAS号 : 25526-93-6
货号 : A374199
分子式 : C10H13FN2O4
纯度 : 98%
分子量 : 244.22
MDL号 : MFCD00056058
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(429.94 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 25 mg/mL(102.37 mM)
动物实验配方：
生物活性
描述 Alovudine (3'-Fluoro-3'-deoxythymidine) serves as a marker of DNA synthesis and is less affected by inflammatory changes than 18F-Fluorodeoxyglucose (FDG), making it a more suitable biomarker for pancreatic cancer. Additionally, alovudine exhibits activity against orthopoxviruses[1].[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.09mL

0.82mL

0.41mL

20.47mL

4.09mL

2.05mL

40.95mL

8.19mL

4.09mL
参考文献

[1]Challapalli A, et al. 3'-Deoxy-3'-18F-fluorothymidine positron emission tomography as an early predictor of disease progression in patients with advanced and metastatic pancreatic cancer. Eur J Nucl Med Mol Imaging. 2015 May;42(6):831-40.

[2]Smee DF, et al. A review of compounds exhibiting anti-orthopoxvirus activity in animal models. Antiviral Res. 2003 Jan;57(1-2):41-52.