Platycodin D
产品说明书
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同义名 : | - |
| CAS号 : | 58479-68-8 | |
| 货号 : | A370901 | |
| 分子式 : | C57H92O28 | |
| 纯度 : | 95% | |
| 分子量 : | 1225.324 | |
| MDL号 : | MFCD09952590 | |
| 存储条件： |
Pure form Keep in dark place,Inert atmosphere,2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 50 mg/mL(40.81 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Platycodin D (PLD) is a natural product isolated and purified from the root of Platycodon grandiflorum., which may stimulate TNF-α synthesis or inhibit degradation of TNF-α mRNA, and is an Hsp90 inhibitor which disrupting the co-chaperone interaction of Hsp90/cell division cycle protein 37 (Cdc37) and subsequently degrading multiple Hsp90 client proteins without the feedback increase of Hsp70[3]. Platycodin D repressed the osteoclast activity and enhanced bone mineral density in the mouse model. In C3H10T1/2 cells, platycodin D upregulated osteogenic markers including alkaline phosphatase (ALP), bone sialoprotein, and collagen type 1 alpha 1, and transcription factors, such as Runx2 and osterix, subsequently enhancing the bone mineralization. Furthermore, platycodin D upregulated the ALP activity and enhanced the mineralization process in osteoblast cells via the sirtuin 1/β-catenin pathways[4]. Platycodin D reduces the protein level of PD-L1 in lung cancer cells via triggering its release into the cell culture medium[5]. PLD protected BV-2 cells from MPP+(1-methyl-4-phenylpyridinium) -induced inflammatory response via regulating the TLR4-MyD88-NF-κB signaling pathway[6]. PLD executes its protective effects on OGD/R(oxygen-glucose deprivation/reperfusion)-induced cell injury via regulating the PI3K/Akt/mTOR pathway in cortical neurons[7]. | ||
| 实验方案 | |||
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| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
0.82mL 0.16mL 0.08mL |
4.08mL 0.82mL 0.41mL |
8.16mL 1.63mL 0.82mL |
| 参考文献 |
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