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Ibutamoren Mesylate

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Chemical Structure| 159752-10-0 同义名 : MK-677;MK-0677;L-163,191;Ibutamoren (mesylate)
CAS号 : 159752-10-0
货号 : A370432
分子式 : C28H40N4O8S2
纯度 : 98%
分子量 : 624.769
MDL号 : MFCD00942284
存储条件：

粉末 Keep in dark place,Inert atmosphere,Room temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(80.03 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 50 mg/mL(80.03 mM)
动物实验配方：
生物活性
描述 MK-677 is a potent, orally active growth hormone (GH) secretagogue with EC50 value of 1.3nM for releasing GH from rat pituitary cells in culture. Addition of 10nM MK-677 elicited transient elevations of cytosolic free calcium through the activation of L-type Ca2+ channels in rat somatotrophs. MK-677 at concentration of 0.1μM greatly potentiated the effect of GHRH (10nM) on GH release and the accumulation of intracellular cAMP in the pituitary cell assay. Elevation of GH could be observed in dogs after oral doses of MK-677 as low as 0.125mg/kg, without significant effect on plasma levels of aldosterone, luteinizing hormone, thyroxine, and prolactin after oral administration of 1 mg/kg.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.60mL

0.32mL

0.16mL

8.00mL

1.60mL

0.80mL

16.01mL

3.20mL

1.60mL
参考文献

[1]Prahalada S, et al. Insulin-like growth factor-1 and growth hormone (GH) levels in canine cerebrospinal fluid are unaffected by GH or GH secretagogue (MK-0677) administration. Horm Metab Res. 1999 Feb-Mar;31(2-3):133-7.

[2]Zheng H, et al. Somatostatin receptor subtype 2 knockout mice are refractory to growth hormone-negative feedback on arcuate neurons. Mol Endocrinol. 1997 Oct;11(11):1709-17.

[3]Hickey GJ, et al. Repeat administration of the GH secretagogue MK-0677 increases and maintains elevated IGF-I levels in beagles. J Endocrinol. 1997 Feb;152(2):183-92.

[4]Jacks T, et al. MK-0677, a potent, novel, orally active growth hormone (GH) secretagogue: GH, insulin-like growth factor I, and other hormonal responses in beagles. Endocrinology. 1996 Dec;137(12):5284-9.