RSV604

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Chemical Structure| 676128-63-5 同义名 : A-60444
CAS号 : 676128-63-5
货号 : A370361
分子式 : C22H17FN4O2
纯度 : 99%
分子量 : 388.394
MDL号 : -
存储条件：

Pure form Keep in dark place,Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(270.34 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 RSV604 is an inhibitor of respiratory syncytial virus replication (EC50=0.86 μM) and a putative RSV nucleoprotein (N) inhibitor.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.57mL

0.51mL

0.26mL

12.87mL

2.57mL

1.29mL

25.75mL

5.15mL

2.57mL
参考文献

[1]Challa S, Scott AD, et al. Mechanism of action for respiratory syncytial virus inhibitor RSV604. Antimicrob Agents Chemother. 2015 Feb;59(2):1080-7.

[2]Henderson EA, Alber DG, et al. 1,4-benzodiazepines as inhibitors of respiratory syncytial virus. The identification of a clinical candidate. J Med Chem. 2007 Apr 5;50(7):1685-92.