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N-Desmethylclozapine

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Chemical Structure| 6104-71-8 同义名 : Norclozapine;Desmethylclozapine;Demethylclozapine.;ACP-104;Normethylclozapine
CAS号 : 6104-71-8
货号 : A369383
分子式 : C17H17ClN4
纯度 : 99%
分子量 : 312.797
MDL号 : MFCD00210189
存储条件:

粉末 Keep in dark place,Inert atmosphere,Room temperature

液体 -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 50 mg/mL(159.85 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方:
生物活性
描述 N-Desmethylclozapine is a dengue virus inhibitor, and an agonist of δ-opioid receptor.
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00501618 Schizophrenia ... 展开 >> Schizoaffective Disorder 收起 << Phase 4 Completed - United States, New York ... 展开 >> Manhattan Psychiatric Center, 125th Street, Out Patient Clinic New York, New York, United States, 10027 Manhattan Psychiatric Center, Inpatient Unit New York, New York, United States, 10035 收起 <<
NCT02286206 Psychotic Disorders ... 展开 >> Schizophrenia 收起 << Phase 4 Active, not recruiting December 2017 Canada, British Columbia ... 展开 >> UBC Hospital - Detwiller Pavilion Vancouver, British Columbia, Canada, V6T 2A1 收起 <<
NCT02625103 Schizophrenia Phase 4 Completed - Denmark ... 展开 >> Psychiatric Centre Rigshospitalet Copenhagen, København Ø, Denmark, 2100 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.20mL

0.64mL

0.32mL

15.98mL

3.20mL

1.60mL

31.97mL

6.39mL

3.20mL

参考文献

[1]Medigeshi GR, Kumar R, et al. N-Desmethylclozapine, Fluoxetine, and Salmeterol Inhibit Postentry Stages of the Dengue Virus Life Cycle. Antimicrob Agents Chemother. 2016 Oct 21;60(11):6709-6718.

[2]Odagaki Y, Kinoshita M, et al. Comparative analysis of pharmacological properties of xanomeline and N-desmethylclozapine in rat brain membranes. J Psychopharmacol. 2016 Sep;30(9):896-912.