产品说明书

KHK-IN-1

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Chemical Structure| 1303469-70-6 同义名 : -
CAS号 : 1303469-70-6
货号 : A366857
分子式 : C21H26N8S
纯度 : 99+%
分子量 : 422.55
MDL号 : -
存储条件：

粉末

液体 -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 KHK-IN-1 is a potent ketohexokinase (KHK) inhibitor with IC50 of 12 nM and interacts with Asp-27B in the ATP-binding region of KHK.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.37mL

0.47mL

0.24mL

11.83mL

2.37mL

1.18mL

23.67mL

4.73mL

2.37mL
参考文献

[1]Maryanoff BE, O'Neill JC, et al. Pyrimidinopyrimidine inhibitors of ketohexokinase: exploring the ring C2 group that interacts with Asp-27B in the ligand binding pocket. Bioorg Med Chem Lett. 2012 Aug 15;22(16):5326-9.

[2]Maryanoff BE, O'Neill JC, et al. Inhibitors of Ketohexokinase: Discovery of Pyrimidinopyrimidines with Specific Substitution that Complements the ATP-Binding Site. ACS Med Chem Lett. 2011 Apr 18;2(7):538-43.