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Exendin(9-39) amide

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Chemical Structure| 133514-43-9 同义名 : Avexitide;Exendin (9-39);Exendin-3 (9-39) amide
CAS号 : 133514-43-9
货号 : A365920
分子式 : C149H234N40O47S
纯度 : 99%
分子量 : 3369.757
MDL号 : MFCD02179664
存储条件：

粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

H2O: 50 mg/mL(14.84 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 Glucagon-like peptide-1 (GLP-1) is a product of proglucagon cleavage synthesized in L cells in the intestinal mucosa, α-cells in the pancreatic islet, and neurons in the nucleus of the solitary tract. GLP-1 is released in response to nutrient absorption in the gut and helps to stimulate insulin secretion in the pancreaticb-cells while also suppressing glucagonsecretion[1]. GLP-1 plays a role in the control of fasting glucose. Avexitide (Exendin (9-39)), a truncated form of the GLP-1 agonist exendin-4, is a specific GLP-1 receptor antagonist. Exendin-(9-39) prevents hypoglycemia and maintains stability of blood glucose during a prolonged fast in individuals with KATPHI.[2]. It is an antagonist of the action of GLP-1(7-36) amide on arterial blood pressure and heart rate of rats. (3000ng of exendin 3-39 and 10ng of GLP-1 (7-36) amide)[3]. It inhibits exendin-3-induced increases in cAMP levels in guinea pig pancreas cells (IC50 = 20 nM)[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

0.30mL

0.06mL

0.03mL

1.48mL

0.30mL

0.15mL

2.97mL

0.59mL

0.30mL
参考文献

[1]Doyle ME, Egan JM. Mechanisms of action of glucagon-like peptide 1 in the pancreas. Pharmacol Ther. 2007. 113:546–93.

[2]Calabria AC, et al. GLP-1 receptor antagonist exendin-(9-39) elevates fasting blood glucose levels in congenital owing to inactivating mutations in the ATP-sensitive K+ channel. Diabetes. 2012. 61(10), 2585-91.

[3]Barragan J. M. et al. Interations of exendin-(9-39) with the effects of glucagon-like peptide-1-(-36) amide and of exendin-4 on arterial blood pressure and heart rate in rats. ELSEVIER. 1996. 67(1), 63-68.

[4]Ruffman, J.-P., Singh, L., and Eng, J. Exendin-3, a novel peptide from Heloderma horridum venom, interacts with vasoactive intestinal peptide receptors and a newly described receptor on dispersed acini from guinea pig pancreas. Description of exendin-3(9-39) amide, a specific exendin receptor antagonist. J. Biol. Chem. 1991. 266(5), 2897-2902.