产品说明书
Sulbutiamine
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同义名 : | Bisibuthiamine;Vitaberin;Arcalion;Youvitan;Bisibutiamine |
| CAS号 : | 3286-46-2 | |
| 货号 : | A363144 | |
| 分子式 : | C32H46N8O6S2 | |
| 纯度 : | 98% | |
| 分子量 : | 702.888 | |
| MDL号 : | MFCD01726427 | |
| 存储条件： |
粉末 Inert atmosphere,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(149.38 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Sulbutiamine is a highly lipid soluble synthetic analogue of vitamin B1, used for the treatment of asthenia. Sulbutiamine is able to attenuate trophic factor deprivation induced apoptotic cell death in neuronal cells in culture. Sulbutiamine attenuates apoptotic cell death induced by serum deprivation and stimulates GSH ( glutathione) and GST (glutathione-S-transferase) activity in a dose dependent manner. Furthermore, sulbutiamine decreases the expression of cleaved caspase-3 and AIF[2]. Sulbutiamine shows neuroprotective effects on hippocampal CA1 pyramidal neurons subjected to oxygen-glucose deprivation. Exposure to OGD (oxygen-glucose deprivation) in the presence of sulbutiamine significantly increases neuronal viability and enhances electrophysiological properties such as excitatory synaptic transmissions and intrinsic neuronal membrane input resistance in a concentration-dependent manner[3]. Sulbutiamine is a lipophilic compound that crosses the blood-brain barrier more readily than thiamine and increases the levels of thiamine and thiamine phosphate esters in the brain. Sulbutiamin appears to be effective in treating fatigue in MS(multiple sclerosis); particularly in patients who were on some DMT(disease modifying treatment), but not on those who were not[4]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
1.42mL 0.28mL 0.14mL |
7.11mL 1.42mL 0.71mL |
14.23mL 2.85mL 1.42mL |
| 参考文献 |
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