产品说明书
Deoxycholic Acid
 |
同义名 : | 去氧胆酸 ;Cholanoic Acid;Desoxycholic acid;7Deoxycholic acid Desoxycholic acid. DCA.;312dihydroxy5cholanate;DCA;Deoxycholic Acid MaxSpec® Standard;Cholorebic;Cholerebic;Deoxycholate |
| CAS号 : | 83-44-3 | |
| 货号 : | A359830 | |
| 分子式 : | C24H40O4 | |
| 纯度 : | 98% | |
| 分子量 : | 392.572 | |
| MDL号 : | MFCD00003673 | |
| 存储条件： |
粉末 Sealed in dry,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : |
DMSO: 105 mg/mL(267.47 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
|
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Deoxycholic Acid is produced by dehydrogenation of primary bile acids by intestinal bacteria. Deoxycholic Acid (1–50 μM) inhibits pacemaker currents in a dose-dependent manner in ICC (interstitial cells of Cajal ). In addition, deoxycholic acid may activate KATP channels in ICC and affect COX-2 (cyclooxygenase-2) activity [3]. Deoxycholic Acid activated EGFR (epidermal growth factor receptor) and promoted intestinal carcinogenesis by ADAM17‐dependent ligand[4]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT02817620 | Metabolic Syndrome | Not Applicable | Completed | - | France ... 展开 >> Biofortis Mérieux NutriSciences Clinical Investigation Center Saint Herblain, France, 44800 收起 << |
| NCT03205176 | Malignant Solid Tumors ... 展开 >> Lymphoma Ovarian Cancer 收起 << | Phase 1 | Recruiting | July 26, 2019 | United States, Florida ... 展开 >> Research Site Recruiting Sarasota, Florida, United States, 34232 United States, Oklahoma Research Site Recruiting Oklahoma City, Oklahoma, United States, 73104 United States, Tennessee Research Site Recruiting Nashville, Tennessee, United States, 37203 收起 << |
| NCT03510052 | Accidental Bowel Leakage ... 展开 >> Fecal Incontinence Incontinence Bowel Incontinence 收起 << | Not Applicable | Recruiting | January 1, 2019 | United States, Pennsylvania ... 展开 >> Hospital of the University of Pennsylvania Recruiting Philadelphia, Pennsylvania, United States, 19104 Contact: Nancy Ejike Principal Investigator: Uduak Andy, MD 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
2.55mL 0.51mL 0.25mL |
12.74mL 2.55mL 1.27mL |
25.47mL 5.09mL 2.55mL |
| 参考文献 |
|---|