产品说明书

	同义名 :	MK-341 sodium;SB 252218 sodium
	CAS号 :	104931-56-8
	货号 :	A357558
	分子式 :	C18H16NNaO5
	纯度 :	99%+
	分子量 :	349.313
	MDL号 :	MFCD14584862
	存储条件：	粉末 Inert atmosphere,Room Temperature 液体 -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性
描述	Tranilast sodium (MK-341 sodium) serves as an anti-atopic agent and is effective in suppressing the production of prostaglandin D2 (PGD2) with an IC50 of 0.1 mM. This compound is known for its anti-inflammatory and immunomodulatory effects[1]. Furthermore, Tranilast sodium counteracts the actions of angiotensin II and inhibits its biological effects on vascular smooth muscle cells[2].

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	2.86mL 0.57mL 0.29mL	14.31mL 2.86mL 1.43mL	28.63mL 5.73mL 2.86mL

参考文献

[1]K Ikai , et al. Inhibitory Effect of Tranilast on Prostaglandin D Synthetase. Biochem Pharmacol. 1989 Aug 15;38(16):2673-6. [2]K Miyazawa , et al. Tranilast Antagonizes Angiotensin II and Inhibits Its Biological Effects in Vascular Smooth Muscle Cells. Atherosclerosis. 1996 Apr 5;121(2):167-73. [3]E A Capper, et al. Modulation of Human Monocyte Activities by Tranilast, SB 252218, a Compound Demonstrating Efficacy in Restenosis. J Pharmacol Exp Ther. 2000 Dec;295(3):1061-9. [4]Sara Darakhshan, et al. Tranilast Enhances the Anti-Tumor Effects of Tamoxifen on Human Breast Cancer Cells in Vitro. J Biomed Sci. 2013 Oct 21;20(1):76. [5]M Isaji , et al. Tranilast Inhibits the Proliferation, Chemotaxis and Tube Formation of Human Microvascular Endothelial Cells in Vitro and Angiogenesis in Vivo. Br J Pharmacol. 1997 Nov;122(6):1061-6.