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BV6

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Chemical Structure| 1001600-56-1 同义名 : BV-6 free
CAS号 : 1001600-56-1
货号 : A357114
分子式 : C70H96N10O8
纯度 : 99%+
分子量 : 1205.573
MDL号 : MFCD28168021
存储条件:

粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 55 mg/mL(45.62 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方:
生物活性
描述 BV6 is an IAP antagonist with Kd values of o.46nM and 1.3nM for c-IAP and XIAP, respectively. Treatment with BV-6 could cause time (5μM, 2-60min)-dependent c-IAP1 and c-IAP2 ubiquitin degradation in MDA-MB-231 cells. The loss of XIAP can be observed at 8h post treatment. BV-6 led induced caspase-dependent cell death in EVSAT and A2058 cells at concentration ranging in 8-1000nM for 24h concentration-dependently, as well as cell death in MDA-MB-231 at concentration<20nM. And this cell death by BV-6 was TNF dependent. BV-6 at 5μM induced a 15- to 30-fold increase in TNFα mRNA levels and further activated its downstream, both of canonical and noncanonical NF-κB pathways, as the phosphorylation and subsequent proteasomal degradation of IκB, time-dependent increased p52 and p100 and inhibited destabilization of NIK by BV-6 can be observed[1]. After treatment with 10mg/kg BV6, i.p., for 4 weeks could significantly reduce the total number of lesions, the average weight and the surface area of lesions in endometriosis-like model[2].
作用机制 BV-6 can bind to the BIR domains of IAP proteins and then lead to rapid ubiquitination and proteasomal degradation of cIAPs.[1]
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

0.83mL

0.17mL

0.08mL

4.15mL

0.83mL

0.41mL

8.29mL

1.66mL

0.83mL