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BQ-788 sodium salt

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Chemical Structure| 156161-89-6 同义名 : BQ-788 Sodium;BQ-788 (sodium salt);BQ788
CAS号 : 156161-89-6
货号 : A356845
分子式 : C34H50N5NaO7
纯度 : 98%+
分子量 : 663.78
MDL号 : MFCD00797882
存储条件：

粉末 Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 30 mg/mL(45.2 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 20 mg/mL(30.13 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 BQ-788 sodium salt is a potent and selective ETB receptor antagonist, with an IC50 of 1.2 nM for inhibiting ET-1 binding to ETB receptors in human Girrardi heart cells.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.51mL

0.30mL

0.15mL

7.53mL

1.51mL

0.75mL

15.07mL

3.01mL

1.51mL
参考文献

[1]Okada M, et al. BQ-788, a selective endothelin ET(B) receptor antagonist. Cardiovasc Drug Rev. 2002 Winter;20(1):53-66.

[2]Sargent CA, et al. Effect of endothelin antagonists with or without BQ 788 on ET-1 responses in pithed rats. J Cardiovasc Pharmacol. 1995;26 Suppl 3:S216-8.

[3]Fattori V, et al. Differential regulation of oxidative stress and cytokine production by endothelin ETA and ETB receptors in superoxide anion-induced inflammation and pain in mice. J Drug Target. 2016 Oct 5:1-27