5-O-Demethylnobiletin

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Chemical Structure| 2174-59-6 同义名 : 5-Demethylnobiletin;5-hydroxy Nob;NSC 618927;Demethylnobiletin
CAS号 : 2174-59-6
货号 : A355418
分子式 : C20H20O8
纯度 : 99%
分子量 : 388.368
MDL号 : MFCD08458849
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 25 mg/mL(64.37 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 5-O-Demethylnobiletin reduced the oedema formation, cell infiltration, and tissue damage in the inflammation induced by TPA (12- O-tetradecanoylphorbol 13-acetate) in mouse ears, along with the acute oedema induced by carrageenan in mouse paws and the acute PLA (2)-induced (phospholipase A (2)) oedema in mouse paws[2]. 5-Demethylnobiletin and gardenin A (10 - 20 μM) potently induce neurite outgrowth in PC12 cells, accompanied by the expression of neuronal differentiation and synapse formation marker proteins, growth-associated protein-43 (GAP-43), and synaptophysin[3]. Three novel metabolites were identified in mice after oral administration of 5-demethylniobiletin. These metabolites exhibited strong inhibitory effects against human colon cancer cells. For example, metabolites (2 - 4) showed IC50 of 0.12, 5.5, and 4.2 μM in SW620 cells, respectively, while 5-demethylnobiletin at 10 μM only caused 37% inhibition after 72 h of treatment[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.57mL

0.51mL

0.26mL

12.87mL

2.57mL

1.29mL

25.75mL

5.15mL

2.57mL
参考文献

[1]Bas E, Recio MC, et al. Anti-inflammatory activity of 5-O-demethylnobiletin, a polymethoxyflavone isolated from Sideritis tragoriganum. Planta Med. 2006 Feb;72(2):136-42.

[2]Bas E, Recio MC, Giner RM, Máñez S, Cerdá-Nicolás M, Ríos JL. Anti-inflammatory activity of 5-O-demethylnobiletin, a polymethoxyflavone isolated from Sideritis tragoriganum. Planta Med. 2006;72(2):136-142

[3]Chiu SP, Wu MJ, Chen PY, et al. Neurotrophic action of 5-hydroxylated polymethoxyflavones: 5-demethylnobiletin and gardenin A stimulate neuritogenesis in PC12 cells. J Agric Food Chem. 2013;61(39):9453-9463

[4]Zheng J, Song M, Dong P, et al. Identification of novel bioactive metabolites of 5-demethylnobiletin in mice. Mol Nutr Food Res. 2013;57(11):1999-2007