产品说明书
Aticaprant
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同义名 : | CERC-501;Ly2456302;JNJ-67953964 |
| CAS号 : | 1174130-61-0 | |
| 货号 : | A354780 | |
| 分子式 : | C26H27FN2O2 | |
| 纯度 : | 99%+ | |
| 分子量 : | 418.5 | |
| MDL号 : | MFCD22572355 | |
| 存储条件： |
粉末 Keep in dark place,Inert atmosphere,Room temperature 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(250.89 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Aticaprant, also known as CERC-501, binds to the human kappa opioid receptor with high affinity, having a Ki value of 0.807 nM. Its affinity is 30 times greater for the human mu opioid receptor and 190 times greater for the human delta opioid receptor. Aticaprant shows no significant affinity for several non-opioid cell surface G-protein coupled receptor targets, including monoaminergic, muscarinic, cholinergic, and adrenergic receptors, or ion channel/transport protein binding targets or the central benzodiazepine binding site[1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.39mL 0.48mL 0.24mL |
11.95mL 2.39mL 1.19mL |
23.89mL 4.78mL 2.39mL |
| 参考文献 |
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