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Madecassic acid

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Chemical Structure| 18449-41-7 同义名 : Brahmic Acid;NSC 88135
CAS号 : 18449-41-7
货号 : A354620
分子式 : C30H48O6
纯度 : 99%+
分子量 : 504.699
MDL号 : MFCD11559128
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 60 mg/mL(118.88 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Madecassic acid, a natural product isolated and purified from the herbs of Centella asiatica (L.) Urban, has anti-inflammatory properties by iNOS, COX-2, TNF-alpha, IL-1beta, and IL-6 inhibition via the downregulation of NF-kappaB activation in RAW 264.7 macrophage cells.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.98mL

0.40mL

0.20mL

9.91mL

1.98mL

0.99mL

19.81mL

3.96mL

1.98mL
参考文献

[1]Xia B, Bai L, et al. Structural analysis of metabolites of asiatic acid and its analogue madecassic acid in zebrafish using LC/IT-MSn. Molecules. 2015 Feb 12;20(2):3001-19.

[2]Wang T, Leng DD, et al. A LC-ESI-MS method for the simultaneous determination of madecassoside and its metabolite madecassic acid in rat plasma: comparison pharmacokinetics in normal and collagen-induced arthritic rats. Chin J Nat Med. 2014 Dec;12(12):943-51.