Acetylshikonin

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Chemical Structure| 24502-78-1 同义名 : -
CAS号 : 24502-78-1
货号 : A353729
分子式 : C18H18O6
纯度 : 99%
分子量 : 330.332
MDL号 : MFCD00143538
存储条件：

Pure form Inert atmosphere,Store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(151.36 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Acetyl shikonin, a natural product isolated and purified from the roots of Lithosperraum erythrorhizon Sieb. et Zucc., inhibits the generation of NADPH oxidase complex in the activation of respiratory burst of PMNs, but does not directly inhibit the activity of NADPH oxidase already generated, and is a non-selective cytochrome P450 inhibitor.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.03mL

0.61mL

0.30mL

15.14mL

3.03mL

1.51mL

30.27mL

6.05mL

3.03mL
参考文献

[1]Shon JC, Phuc NM, et al. Acetylshikonin is a Novel Non-selective Cytochrome P450 Inhibitor. Biopharm Drug Dispos. 2017 Sep 3.

[2]Ozaki Y, Ohno A, et al. Accelerative effect of shikonin, alkannin and acetylshikonin on the proliferation of granulation tissue in rats. Biol Pharm Bull. 1994 Aug;17(8):1075-7.