Actein

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Chemical Structure| 18642-44-9 同义名 : -
CAS号 : 18642-44-9
货号 : A353125
分子式 : C37H56O11
纯度 : 98+%
分子量 : 676.83
MDL号 : MFCD25371991
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(155.13 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Actein, a natural product isolated and purified from the roots of Cimicifuga racemosa with stimulatory effect on osteoblastic bone formation and potential activity against osteoporosis, has been shown to inhibit the proliferation of human breast cancer cells, by altering the activity of the ER IP3 receptor and Na,K-ATPase, inducing calcium release and modulating the NF-κB and MEK pathways, and reduces free fatty acid and cholesterol content in the liver by 0.6-fold at 24 h and inhibites the growth of human HepG2 liver cancer cells.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.48mL

0.30mL

0.15mL

7.39mL

1.48mL

0.74mL

14.77mL

2.95mL

1.48mL
参考文献

[1]Lee YS, Choi EM. Actein isolated from black cohosh promotes the function of osteoblastic MC3T3-E1 cells. J Med Food. 2014 Apr;17(4):414-23.

[2]Einbond LS, Mighty J, Redenti S, Wu HA. Actein induces calcium release in human breast cancer cells. Fitoterapia. 2013 Dec;91:28-38.