6-Biopterin

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Chemical Structure| 22150-76-1 同义名 : L-Biopterin;L-erythro-Biopterin;tetrahybiopterin;LS126316;AR 1D8544;NSC 339699
CAS号 : 22150-76-1
货号 : A350774
分子式 : C9H11N5O3
纯度 : 99%+
分子量 : 237.215
MDL号 : MFCD00036787
存储条件:

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 12 mg/mL(50.59 mM),配合低频超声,并水浴加热至45℃助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方:
生物活性
描述 6-Biopterin (L-Biopterin), a pterin derivative, is an oxidation product from the melanogenesis regulating cofactor (6R)5,6,7,8 tetrahydrobiopterin (6-BH4). 6-Biopterin (L-Biopterin), a pterin derivative, is a NO synthase cofactor. The oxidized cofactor 6-biopterin (0.2 x 10(-6) M) is extremely cytotoxic to human melanocytes under in vitro conditions[1]. Full oxidation of 6BH(4) to 6 biopterin via H(2)O(2) can lead to a cytotoxic environment for epidermal melanocytes[2]. Dihydropterin and 6-biopterin, the oxidation products of 6-BH4, do not inhibit tyrosinase significantly, indicating that melanin biosynthesis is controlled by a 6-BH4/6-biopterin redox-switch mechanism which can be initiated by photo-oxidation of 6-BH4[3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.22mL

0.84mL

0.42mL

21.08mL

4.22mL

2.11mL

42.16mL

8.43mL

4.22mL

参考文献

[1]Schallreuter KU, Büttner G, Pittelkow MR, Wood JM, Swanson NN, Körner C. Cytotoxicity of 6-biopterin to human melanocytes. Biochem Biophys Res Commun. 1994 Oct 14;204(1):43-8

[2]Schallreuter KU, Wood JM. Thioredoxin reductase - its role in epidermal redox status. J Photochem Photobiol B. 2001 Nov 15;64(2-3):179-84

[3]Wood JM, Schallreuter-Wood KU, Lindsey NJ, Callaghan S, Gardner ML. A specific tetrahydrobiopterin binding domain on tyrosinase controls melanogenesis. Biochem Biophys Res Commun. 1995 Jan 17;206(2):480-5