产品说明书

Valbenazine

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Chemical Structure| 1025504-45-3 同义名 : NBI-98854
CAS号 : 1025504-45-3
货号 : A348606
分子式 : C24H38N2O4
纯度 : 98+%
分子量 : 418.57
MDL号 : MFCD28963976
存储条件：

粉末 Keep in dark place,Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(119.45 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Valbenazine is a potent inhibitor of the vesicular monoamine transporter 2 (VMAT2), with a Ki range of 110-190 nM[1].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02679079 Tourette Syndrome Phase 2 Completed - -
NCT02879578 Tourette Syndrome Phase 2 Completed - United States, Arizona ... 展开 >> Sun City, Arizona, United States United States, California San Diego, California, United States United States, Florida Loxahatchee Groves, Florida, United States Saint Petersburg, Florida, United States Tampa, Florida, United States United States, Illinois Naperville, Illinois, United States United States, Nebraska Lincoln, Nebraska, United States United States, New Jersey Summit, New Jersey, United States United States, New York New York, New York, United States United States, Pennsylvania Norristown, Pennsylvania, United States United States, Tennessee Nashville, Tennessee, United States United States, Texas Fort Worth, Texas, United States United States, Washington Spokane, Washington, United States 收起 <<
NCT02581865 Tourette Syndrome Phase 2 Completed - -
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.39mL

0.48mL

0.24mL

11.95mL

2.39mL

1.19mL

23.89mL

4.78mL

2.39mL
参考文献

[1]Dimitri E Grigoriadis, et al. Pharmacologic Characterization of Valbenazine (NBI-98854) and Its Metabolites. J Pharmacol Exp Ther. 2017 Jun;361(3):454-461.