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Deoxypodophyllotoxin

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Chemical Structure| 19186-35-7 同义名 : 去氧鬼臼毒素 ;Anthricin;RD4-6266;AS2-3;DPT;4-Deoxypodophyllotoxin;(–)-Deoxypodophyllotoxin
CAS号 : 19186-35-7
货号 : A348526
分子式 : C22H22O7
纯度 : 98%
分子量 : 398.41
MDL号 : MFCD01699018
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(263.55 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Deoxypodophyllotoxin, a natural microtube inhibitor isolated and purified from the roots of Dysosma versipellis (Hance) M.Cheng ex Ying, is cytotoxic agent, antineoplastic agent and potent antitumor agent and may be beneficial in regulating the immediate-type allergic reaction.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.51mL

0.50mL

0.25mL

12.55mL

2.51mL

1.25mL

25.10mL

5.02mL

2.51mL
参考文献

[1]Zang X, Wang G, et al. A Promising Microtubule Inhibitor Deoxypodophyllotoxin Exhibits Better Efficacy to Multi-Drug Resistant Breast Cancer than Paclitaxel via Avoiding Efflux Transport. Drug Metab Dispos. 2018 Mar 9. pii: dmd.117.079442.

[2]Guerram M, Jiang ZZ, et al. Antineoplastic effects of deoxypodophyllotoxin, a potent cytotoxic agent of plant origin, on glioblastoma U-87 MG and SF126 cells. Pharmacol Rep. 2015 Apr;67(2):245-52.