Genipin
产品说明书
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同义名 : | (+)-Genipin |
| CAS号 : | 6902-77-8 | |
| 货号 : | A346395 | |
| 分子式 : | C11H14O5 | |
| 纯度 : | 98% | |
| 分子量 : | 226.226 | |
| MDL号 : | MFCD00888600 | |
| 存储条件： |
Pure form Inert atmosphere,Room Temperature In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(464.14 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 4 mg/mL(17.68 mM)，配合低频超声助溶 |
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| 动物实验配方： |
| 生物活性 | |||
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| 描述 | Genipin is an effective cross-linking reagent derived from Gardenia jasminoides Ellis fruits. Genipin at a concentration of 50μM inhibited superoxide-activated, uncoupling protein 2-mediated mitochondrial proton leak in the mitochondria isolated from mouse kidney.[4] Genipin increased glucose uptake in C2C12 myotubes in a dose-dependent (1 – 10μM) and time-dependent (0.5 – 2 hours) manner. Also in C2C12 myotubes, 10 μM of genipin increased the cellular concentrations of adenosine triphosphate and reactive oxygen species within 30 min of incubation.[5] Intraperitoneal administration of genipin at a dose of 25mg/kg/day for 7 days attenuated depression-like behaviors and normalized reduced hippocampal Bdnf expression in young adult PRS mice.[3] | ||
| 作用机制 | Genipin is a monoterpenoid compound with multiple bioactive properties, such as anti-inflammatory, anti-angiogenic, and anti-depressive activities.[3] | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
4.42mL 0.88mL 0.44mL |
22.10mL 4.42mL 2.21mL |
44.20mL 8.84mL 4.42mL |
| 参考文献 |
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