生物活性 | |||
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描述 | AS057278, a potent in vitro (IC50=0.91 mM) and ex vivo (ED50=2.2-3.95 mM) DAAO inhibitor, was able to increase d-serine fraction in rat cortex and midbrain (10 mg/kg i.v.). AS057278 was able to normalize phencyclidine (PCP)-induced prepulse inhibition after acute (80 mg/kg) and chronic (20 mg/kg b.i.d.) oral administration in mice. AS057278 after oral chronic treatment (10 mg/kg b.i.d.) was able to normalize PCP-induced hyperlocomotion[2]. Pretreatment with AS057278 significantly suppressed the DA release induced by d-Trp[3]. The effect of insulin in restoration of PDHP phosphatase activity of starved rats was not mimicked by AS057278[4]. Rats made tolerant to nicotinic acid also became tolerant to both AS057278 and to pyridyl-3-tetrazole and rats made tolerant to these antilipolytic agents were also tolerant to nicotinic acid[5]. |
实验方案 | |||
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1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
7.93mL 1.59mL 0.79mL |
39.65mL 7.93mL 3.96mL |
79.30mL 15.86mL 7.93mL |
参考文献 |
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