产品说明书

Skepinone-L

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Chemical Structure| 1221485-83-1 同义名 : CBS3830
CAS号 : 1221485-83-1
货号 : A342976
分子式 : C24H21F2NO4
纯度 : 98%
分子量 : 425.425
MDL号 : MFCD22572738
存储条件：

粉末 Keep in dark place,Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(117.53 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：

0.5% methylcellulose+water 30 mg/mL suspension

生物活性
靶点

  • p38α

    p38α, IC50:5 nM
描述 Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.35mL

0.47mL

0.24mL

11.75mL

2.35mL

1.18mL

23.51mL

4.70mL

2.35mL
参考文献

[1]Borst O, Walker B, et al. Skepinone-L, a novel potent and highly selective inhibitor of p38 MAP kinase, effectively impairs platelet activation and thrombus formation. Cell Physiol Biochem. 2013;31(6):914-24.

[2]Koeberle SC, Romir J, et al. Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor. Nat Chem Biol. 2011 Dec 25;8(2):141-3.