AT6
产品说明书
 |
同义名 : | - |
| CAS号 : | 2098836-50-9 | |
| 货号 : | A341809 | |
| 分子式 : | C48H58ClN9O7S3 | |
| 纯度 : | 98% | |
| 分子量 : | 1004.678 | |
| MDL号 : | N/A | |
| 存储条件： |
Pure form In solvent -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : |
DMSO: 105 mg/mL(104.51 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
|
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | AT6 is an analogue of highly selective Brd4 degrader AT1, bearing thioether linkages of varying lengths. It led a dose-dependent degradation of BRD4 at concentration ranging in 30nM-3μM in HeLa cells. It works as a PROTAC selectively targeting on Brd4[1]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT00908986 | Lupus Nephritis | Not Applicable | Withdrawn(Terminated by sponso... 展开 >>r) 收起 << | - | - |
| NCT01899365 | - | Active, not recruiting | October 2017 | France ... 展开 >> Centre Hospitalier Universitaire de Clermont-Ferrand Clermont-ferrand, France, 63003 Centre Hospitalier Paul Ardier Issoire, France, 63503 AP-HM - Hôpital Nord Marseille, France, 13015 AP-HM - La Timone Marseille, France, 13385 HIA Laveran Marseille, France, 13915 Centre Hospitalier La Palmosa Menton, France, 06507 Centre Hospitalier Universitaire de Nice Nice, France, 06003 Centre Hospitalier Louis Giorgi Orange, France, 84106 Hôpital Lariboisière Paris, France, 75010 Hôpital Pitié-Salpêtrière Paris, France, 75013 Hôpital Bichat-Claude Bernard Paris, France, 75018 Hôpital Tenon Paris, France, 75020 Hôpital Cochin Paris, France, 75679 Centre hospitalier de Saint-Denis Saint-denis, France, 93200 Centre Hospitalier de Vaison-la-Romaine Vaison-la-romaine, France, 84110 Centre Hospitalier Jules Niel Valreas, France, 84600 Centre Hospitalier Jacques Lacarin Vichy, France, 03207 Monaco Centre Hospitalier Princesse Grace Monaco, Monaco, 98000 收起 << | |
| NCT01474096 | Breastfeeding | Not Applicable | Completed | - | Spain ... 展开 >> Gerencia Atención Primaria, Madrid Madrid, Spain 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
1.00mL 0.20mL 0.10mL |
4.98mL 1.00mL 0.50mL |
9.95mL 1.99mL 1.00mL |
| 参考文献 |
|---|