产品说明书

Trioxsalen

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Chemical Structure| 3902-71-4 同义名 : Trisoralen;Trioxysalen;Trioxsalen, trimethylpsoralen, Trioxysalen;4,5’,8-Trimethylpsoralen;NSC 71047;TMP
CAS号 : 3902-71-4
货号 : A341643
分子式 : C14H12O3
纯度 : 98%
分子量 : 228.243
MDL号 : MFCD00005010
存储条件:

粉末 Keep in dark place,Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 2 mg/mL(8.76 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方:
生物活性
描述 Trioxsalen is a furanocoumarin and a psoralen derivative, in conjunction with UV-A for phototherapy treatment of vitiligo and hand eczema.
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01739465 Cholangiocarcinoma Phase 2 Phase 3 Unknown - China, Guangdong ... 展开 >> The Second Hospital of Guangzhou Medical College Not yet recruiting Guangzhou, Guangdong, China, 510260 Contact: Huihong Liang, MD    +86-188-2648-8232    beanth@163.com    The second hospital of Guangzhou Medical college Recruiting Guangzhou, Guangdong, China, 510260 Contact: Huihong Liang, Doctorial    +86-188-2648-8232    beanth@163.com    Principal Investigator: Huihong Liang, Doctoral 收起 <<
NCT01238042 Barrett's Esophagus ... 展开 >> CIS HGD 收起 << Phase 1 Completed - United States, New York ... 展开 >> Roswell Park Cancer Institute Buffalo, New York, United States, 14263 收起 <<
NCT03564054 Non Small Cell Lung Cancer Not Applicable Recruiting September 2021 United States, Florida ... 展开 >> University of Florida Recruiting Gainesville, Florida, United States, 32608 Contact: Erin Silverman, PhD          Principal Investigator: Hiren Mehta, MD 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.38mL

0.88mL

0.44mL

21.91mL

4.38mL

2.19mL

43.81mL

8.76mL

4.38mL

参考文献

[1]Sanchez Ruderisch H, Schwarz C, et al. Trioxsalen in the presence of UVA is able to induce nuclear factor kappa B binding activity in HaCaT keratinocytes. Skin Pharmacol Appl Skin Physiol. 2002 Sep-Oct;15(5):335-41.

[2]Hannuksela-Svahn A, Sigurgeirsson B, et al. Trioxsalen bath PUVA did not increase the risk of squamous cell skin carcinoma and cutaneous malignant melanoma in a joint analysis of 944 Swedish and Finnish patients with psoriasis. Br J Dermatol. 1999 Sep;141(3):497-501.