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NADPH tetrasodium salt

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Chemical Structure| 2646-71-1 同义名 : 还原型辅酶II ;NADPH (sodium salt);Nicotinamide adenine dinucleotide phosphate
CAS号 : 2646-71-1
货号 : A341469
分子式 : C21H26N7Na4O17P3
纯度 : 98%
分子量 : 833.348
MDL号 : MFCD00036263
存储条件：

粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

H2O: 35 mg/mL(42 mM)
动物实验配方：
生物活性
描述 NADPH tetrasodium salt is a cofactor, used to donate electrons and hydrogens to reactions catalyzed by some enzymes. NADPH tetrasodium salt is the reduced form of the electron acceptor nicotinamide adenine dinucleotide phosphate (NADP+) and acts as an electron donor in various biological reactions. NADPH is the reduced form of NADP+. NADP+ differs from NAD+ in the presence of an additional phosphate group on the 2' position of the ribose ring that carries the adenine moiety[1]. NADPH provides the reducing equivalents for biosynthetic reactions and the oxidation-reduction involved in protecting against the toxicity of reactive oxygen species[2]. It is also used for the synthesis of lipids and cholesterol and during the process of fatty acid chain elongation[3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.20mL

0.24mL

0.12mL

6.00mL

1.20mL

0.60mL

12.00mL

2.40mL

1.20mL
参考文献

[1]Sumimoto H. Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species. FEBS J. 2008 Jul;275(13):3249-77

[2]Sutherland, M.W., Nelson, J., Harrison, G., et al. Effects of t-butyl hydroperoxide on NADPH, glutathione, and the respiratory burst of rat alveolar machrophages. Arch. Biochem. Biophys. 1985;243(2), 325-331.

[3]Tserng, K.Y., and Jin, S.J. NADPH-dependent reductive metabolism of cis-5 unsaturated fatty acids. A revised pathway for the β-oxidation of oleic acid. The Journal of Biological Chemisty. 1990; 266(18), 11614-11620.