Deferasirox

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Chemical Structure| 201530-41-8 同义名 : ICL 670;ICL670A;Desifer.;Defrijet;Desirox;Deferasirox. Brand name: Exjade;CGP-72670
CAS号 : 201530-41-8
货号 : A340437
分子式 : C21H15N3O4
纯度 : 98%
分子量 : 373.361
MDL号 : MFCD09951804
存储条件：

Pure form Keep in dark place,Inert atmosphere,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(281.23 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：

5% DMSO+40% PEG 300+5%Tween 80 +50 % water 3.7 mg/mL

生物活性
描述 Deferasirox (ICL 670) is an orally administered iron chelator designed to manage transfusional iron overload[1].[2].[3].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01441375 - Completed - United States, Louisiana ... 展开 >> Tulane University New Orleans, Louisiana, United States, 70112 United States, Tennessee Universit of Tennessee Memphis, Tennessee, United States, 38163 收起 <<
NCT01838291 - Completed - Cyprus ... 展开 >> Thalassemia Center of North Cyprus Turkish Republic (KKTC) Nicosia, Cyprus Egypt Hematology Unit, El-Shatby Children Hospital, Alexandria University Alexandria, Egypt Hematology Unit, Assiut University Hospital Assiut, Egypt Ain Shams University Cairo, Egypt Hematology Unit, Mansoura University Children Hospital Mansoura, Egypt Tanta University Hospital Tanta, Egypt Hematology/Oncology Unit ; Zagazig University Children Hospital Zagazig, Egypt Zagazig University; Thalassemia Association Zagazig, Egypt Oman Department of Child Health, College of Medicine and Health Sciences, Sultan Qaboos University Hospital Muscat, Oman Saudi Arabia King Abdulaziz University Hospital (KAAUH) Jeddah, Saudi Arabia Maternity and Children's Hospital Maddinah, Saudi Arabia Turkey Çukurova Üniversitesi Tip Fakültesi, Çocuk Hematolojie Bilim Dali Adana, Turkey Akdeniz Üniversitesi Hastanesi, Çocuk Sağliği, Hematolojie Kliniği Antalya, Turkey Ïstanbul Üniversitesi Tip. Fak. Hastanesi, Çocuk Sağliği, Hematolojie Kliniği Istanbul, Turkey 收起 <<
NCT01795794 CDA Type I Phase 4 Unknown December 2013 -
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.68mL

0.54mL

0.27mL

13.39mL

2.68mL

1.34mL

26.78mL

5.36mL

2.68mL
参考文献

[1]Sobbe A, et al. Inconsistent hepatic antifibrotic effects with the iron chelator deferasirox. J Gastroenterol Hepatol. 2015 Mar;30(3):638-45.

[2]Kim JL, et al. The oral iron chelator deferasirox induces apoptosis in myeloid leukemia cells by targetingcaspase. Acta Haematol. 2011;126(4):241-5.

[3]Lee DH, et al. Deferasirox shows in vitro and in vivo antileukemic effects on murine leukemic cell lines regardless of iron status. Exp Hematol. 2013 Jun;41(6):539-46.