产品说明书

Rubiadin

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Chemical Structure| 117-02-2 同义名 : 甲基异茜草素 ;C.I. 75350
CAS号 : 117-02-2
货号 : A338201
分子式 : C15H10O4
纯度 : 98%
分子量 : 254.238
MDL号 : MFCD02752095
存储条件:

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 5 mg/mL(19.67 mM),配合低频超声,并水浴加热至45℃助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方:
生物活性
描述 Rubiadin, a natural product isolated and purified from the roots of Rubia cordifolia with hepatoprotective effects against carbon tetrachloride (CCl 4 )-induced hepatic damage in rats and potent antioxidant property, can prevent lipid peroxidation induced by FeSO4 and t-butylhydroperoxide (t-BHP) in a dose dependent manner, and decrease bone loss through the inhibition of osteoclast formation, differentiation and bone resorption. Rubiadin also exhibits strong antitumor promoting activity at the concentration of 2.0 μg/mL when assayed using the inhibition test of Epstein Barr Virus (EBV) activation on Raji cells.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.93mL

0.79mL

0.39mL

19.67mL

3.93mL

1.97mL

39.33mL

7.87mL

3.93mL

参考文献

[1]Rumie Vittar NB, Comini L, et al. Photochemotherapy using natural anthraquinones: Rubiadin and Soranjidiol sensitize human cancer cell to die by apoptosis. Photodiagnosis Photodyn Ther. 2014 Jun;11(2):182-92.

[2]Baghiani A, Charef N, et al. Free radical scanvenging and antioxidant effects of some anthraquinone derivatives. Med Chem. 2011 Nov;7(6):639-44.