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Forsythoside A

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Chemical Structure| 79916-77-1 同义名 : 连翘脂苷A ;Forsythiaside A;Forsythiaside
CAS号 : 79916-77-1
货号 : A338187
分子式 : C29H36O15
纯度 : 99%+
分子量 : 624.587
MDL号 : MFCD08460220
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(192.13 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(160.11 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 Forsythiaside A, a phenylethanoid glycoside procured from Forsythia suspensa fruits, can be administered orally. It acts as a COX-2 inhibitor and possesses anti-inflammatory, antioxidant, and neuroprotective properties. Forsythiaside A is instrumental in thwarting neuroinflammation and apoptosis prompted by Aβ25-35, rendering it potentially useful in Alzheimer's disease studies. Additionally, it stimulates the Nrf2/HO-1 signaling pathway and mitigates asthma induced by ovalbumin in murine models[1][2][3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.60mL

0.32mL

0.16mL

8.01mL

1.60mL

0.80mL

16.01mL

3.20mL

1.60mL
参考文献

[1]Wang Y, et al. Forsythiaside A Exhibits Anti-inflammatory Effects in LPS-Stimulated BV2 Microglia Cells Through Activation of Nrf2/HO-1 Signaling Pathway. Neurochem Res. 2016 Apr;41(4):659-65.

[2]Chen L, et al. Forsythiaside prevents β-amyloid-induced hippocampal slice injury by upregulating 2-arachidonoylglycerol via cannabinoid receptor 1-dependent NF-κB pathway. Neurochem Int. 2019 May;125:57-66.

[3]Qian J, et al. Protective effect of forsythiaside A on OVA-induced asthma in mice. Eur J Pharmacol. 2017 Oct 5;812:250-255.