DR2313
产品说明书
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同义名 : | PARP Inhibitor XI |
| CAS号 : | 284028-90-6 | |
| 货号 : | A336764 | |
| 分子式 : | C8H10N2OS | |
| 纯度 : | 97% | |
| 分子量 : | 182.243 | |
| MDL号 : | MFCD08703132 | |
| 存储条件： |
Pure form Sealed in dry,2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 12 mg/mL(65.85 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 100 mg/mL(548.72 mM) |
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| 动物实验配方： |
| 生物活性 | |||
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| 描述 | DR2313 is a potent, selective, competitive and brain-penetrating PARP inhibitor with IC50 values of 0.20 μM for PARP-1 and 0.24 μM for PARP-2. DR2313 is neuroprotective against ischaemic injury in vitro and in vivo[1][2].In the concentration range of 0.016-16.4 μM, DR2313 can inhibit the poly(ADP-ribosyl)ation reaction in rat brain nuclear extract for 30 minutes, with a Ki of 0.23 μM. In the concentration range of 1-100 μM, DR2313 showed a weak inhibitory effect on mono(ADP-ribosyl)ation in a concentration-dependent manner for 10 minutes, with an IC50 value of 59 μM. DR2313 reduces hydrogen peroxide (500 μM; 4 hours) or glutamate (1 mM; 30 minutes)-induced poly(ADP-ribose) and cell death in the concentration range of 0.1-30 μM and 30 minutes of pretreatment[1] . | ||
| 实验方案 | |||
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| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
5.49mL 1.10mL 0.55mL |
27.44mL 5.49mL 2.74mL |
54.87mL 10.97mL 5.49mL |
| 参考文献 |
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