产品说明书

Chelerythrine Chloride

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Chemical Structure| 3895-92-9 同义名 : 氯化白屈菜红碱 ;Chelerythrine (chloride);NSC 646662;Broussonpapyrine chloride
CAS号 : 3895-92-9
货号 : A333732
分子式 : C21H18ClNO4
纯度 : 99%
分子量 : 383.825
MDL号 : MFCD00060717
存储条件：

粉末 Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 3 mg/mL(7.82 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Chelerythrine is potent, cell-permeable inhibitor of protein kinase C (IC50 = 660 nM) and competitive with respect to the phosphate acceptor and non-competitive with respect to ATP.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.61mL

0.52mL

0.26mL

13.03mL

2.61mL

1.30mL

26.05mL

5.21mL

2.61mL
参考文献

[1]Li W, Fan T, et al. Effect of chelerythrine against endotoxic shock in mice and its modulation of inflammatory mediators in peritoneal macrophages through the modulation of mitogen-activated protein kinase (MAPK) pathway. Inflammation. 2012 Dec;35(6)

[2] Pěncikova K, Kollar P, et al. inflammatory gene expression in THP-1 cell line. Phytomedicine. 2012 Jul 15;19(10):890-5.