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8-Gingerol

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Chemical Structure| 23513-08-8 同义名 : -
CAS号 : 23513-08-8
货号 : A329272
分子式 : C19H30O4
纯度 : 99%+
分子量 : 322.439
MDL号 : MFCD00877794
存储条件：

粉末 Keep in dark place,Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(325.64 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 8-Gingerol, a natural product isolated and purified from the rhizome of Zingiber officinale Roscoe. with anti-oxidant and anti-inflammatory activities, suppresses lipopolysaccharide (LPS) and concanavalin A (ConA)-stimulated splenocyte proliferation in vitro and cellular tyrosinase activity, inhibits the expression of MC1R, MITF, tyrosinase, TRP1 and TRP2, decreases melanin content, intracellular RS and ROS levels in B16F10 and B16F1 cells, inhibits melanogenesis by down-regulation of MAPK, PKA signaling pathway and it could be used as an effective skin-whitening agent. It also inhibits T lymphocyte proliferation and cytokine synthesis.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.10mL

0.62mL

0.31mL

15.51mL

3.10mL

1.55mL

31.01mL

6.20mL

3.10mL
参考文献

[1]Huang HC, Chou YC, et al. [8] -Gingerol inhibits melanogenesis in murine melanoma cells through down-regulation of the MAPK and PKA signal pathways. Biochem Biophys Res Commun. 2013 Aug 23;438(2):375-81.

[2]Lu J, Guan S, et al. Immunosuppressive activity of 8-gingerol on immune responses in mice. Molecules. 2011 Mar 22;16(3):2636-45.