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LCL521 2HCl

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Chemical Structure| 1226759-47-2 同义名 : LCL521 dihydrochloride
CAS号 : 1226759-47-2
货号 : A328422
分子式 : C31H54Cl2N4O7
纯度 : 98%
分子量 : 665.689
MDL号 : MFCD31692338
存储条件：

粉末 Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 20 mg/mL(30.04 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(150.22 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 LCL521 dihydrochloride, an inhibitor of acid ceramidase, shows anticancer actions of lysosomally targeted.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.50mL

0.30mL

0.15mL

7.51mL

1.50mL

0.75mL

15.02mL

3.00mL

1.50mL
参考文献

[1]Liu F, Li X, et al. Ceramide activates lysosomal cathepsin B and cathepsin D to attenuate autophagy and induces ER stress to suppress myeloid-derived suppressor cells. Oncotarget. 2016 Dec 20;7(51):83907-83925.

[2]Bai A, Szulc ZM, et al. Targeting (cellular) lysosomal acid ceramidase by B13: design, synthesis and evaluation of novel DMG-B13 ester prodrugs. Bioorg Med Chem. 2014 Dec 15;22(24):6933-44.