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L48H37

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Chemical Structure| 343307-76-6 同义名 : -
CAS号 : 343307-76-6
货号 : A321163
分子式 : C27H33NO7
纯度 : 97%
分子量 : 483.553
MDL号 : MFCD08560158
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(103.4 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 L48H37 is a Curcumin analogue exhibiting enhanced chemical stability. It acts as a potent and selective inhibitor of myeloid differentiation protein 2 (MD2), effectively disrupting the interaction and signaling transduction of LPS-TLR4/MD2. L48H37 is employed in research for the treatment of sepsis or lung injury[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.07mL

0.41mL

0.21mL

10.34mL

2.07mL

1.03mL

20.68mL

4.14mL

2.07mL
参考文献

[1]Yi Wang, et al. Curcumin Analog L48H37 Prevents Lipopolysaccharide-Induced TLR4 Signaling Pathway Activation and Sepsis via Targeting MD2. J Pharmacol Exp Ther. 2015 Jun;353(3):539-50

[2]Chen Feng, et al. Curcumin analog L48H37 induces apoptosis through ROS-mediated endoplasmic reticulum stress and STAT3 pathways in human lung cancer cells. Mol Carcinog. 2017 Jul;56(7):1765-1777.