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BU224 HCl

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Chemical Structure| 205437-64-5 同义名 : BU224 hydrochloride
CAS号 : 205437-64-5
货号 : A320075
分子式 : C12H12ClN3
纯度 : 97%
分子量 : 233.697
MDL号 : MFCD00467639
存储条件：

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 12 mg/mL(51.35 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 BU224 hydrochloride is distinguished as a selective ligand with high affinity for the imidazoline I2 receptor, evidenced by a Ki value of 2.1 nM. It is occasionally employed as an antagonist for the I2 receptor. The compound is noted for its neuroprotective qualities, including anti-inflammatory and anti-apoptotic effects. In the context of Alzheimer's disease research, BU224 hydrochloride has been shown to enhance memory in 5XFAD mice models, contributing to the enlargement of dendritic spines and mitigating the alterations in NMDARs induced by Aβ[1][2][3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.28mL

0.86mL

0.43mL

21.40mL

4.28mL

2.14mL

42.79mL

8.56mL

4.28mL
参考文献

[1]Mirzaei N, et al. Imidazoline ligand BU224 reverses cognitive deficits, reduces microgliosis and enhances synaptic connectivity in a mouse model of Alzheimer's disease. Br J Pharmacol. 2021 Feb;178(3):654-671.

[2]Finn DP, et al. Behavioral, neuroendocrine and neurochemical effects of the imidazoline I2 receptor selective ligand BU224 in naive rats and rats exposed to the stress of the forced swim test. Psychopharmacology (Berl). 2003 May;167(2):195-202.

[3]Qiu Y, et al. Discriminative stimulus effects of the imidazoline I2 receptor ligands BU224 and phenyzoline in rats. Eur J Pharmacol. 2015 Feb 15;749:133-41.