产品说明书
Alverine citrate
 |
同义名 : | 枸橼酸阿尔维林 ;NSC 35459;Alverine (citrate) |
| CAS号 : | 5560-59-8 | |
| 货号 : | A319955 | |
| 分子式 : | C26H35NO7 | |
| 纯度 : | 98% | |
| 分子量 : | 473.559 | |
| MDL号 : | MFCD00035086 | |
| 存储条件： |
粉末 Inert atmosphere,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : |
DMSO: 105 mg/mL(221.73 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
PO 0.5% CMC-Na 30 mg/mL suspension |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Alverine citrate, as a selective 5-HT1A receptor subtype antagonist, inhibits the rectal hypersensitivity induced by serotonin, a mediator involved in IBS(Irritable bowel syndrome) hyperalgesia[3]. Alverine citrate is thought of as a smooth muscle relaxant, and is currently used as an antispasmodic in irritable bowel syndrome and dysmenorrhoea. Alverine (10 μM) increased the frequency and amplitude of spontaneous action potentials, transient increases in [Ca2+]i and associated contractions. Alverine suppressed contractions produced by high K (40 mM) or ACh (10 μM), without affecting electrical responses and with little suppression of increases in [Ca2+] [4]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
2.11mL 0.42mL 0.21mL |
10.56mL 2.11mL 1.06mL |
21.12mL 4.22mL 2.11mL |
| 参考文献 |
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