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Memantine HCI

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Chemical Structure| 41100-52-1 同义名 : 美金刚胺盐酸盐 ;D-145 hydrochloride;Memantine (hydrochloride);SUN Y7017;NSC 102290;Namenda;Ebix;Axura;Akatinol;Memantine HCl
CAS号 : 41100-52-1
货号 : A319004
分子式 : C12H22ClN
纯度 : 98%
分子量 : 215.763
MDL号 : -
存储条件：

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(556.17 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 30 mg/mL(139.04 mM)
动物实验配方：
生物活性
描述 Memantine hydrochloride, an amantadine derivative with low to moderate-affinity for NMDA receptors, inhibit CYP2B6 and CYP2D6 with Ki of 0.51 nM and 94.9 μM, respectively, is used for the treatment of Alzheimer's disease.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.63mL

0.93mL

0.46mL

23.17mL

4.63mL

2.32mL

46.35mL

9.27mL

4.63mL
参考文献

[1]Peng D, Yuan X, Zhu R. Memantine hydrochloride in the treatment of dementia subtypes. J Clin Neurosci. 2013 Nov;20(11):1482-5.

[2]Witt A, Macdonald N, Kirkpatrick P. Memantine hydrochloride. Nat Rev Drug Discov. 2004 Feb;3(2):109-10. PubMed PMID: 15040575.