产品说明书

RKI-1447

Print
Chemical Structure| 1342278-01-6 同义名 : -
CAS号 : 1342278-01-6
货号 : A317869
分子式 : C16H14N4O2S
纯度 : 99%+
分子量 : 326.373
MDL号 : MFCD26142658
存储条件：

粉末 Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(153.2 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • ROCK1

    ROCK1, IC50:14.5 nM

  • ROCK2

    ROCK2, IC50:6.2 nM
描述 RKI-1447 is a type I kinase inhibitor that binds ATP binding sites through interactions with hinge regions and DFG motifs. RKI-1447 inhibits phosphorylation of ROCK substrates mLC-2 and MYPT-1 in human cancer cells, but has no effect on phosphorylation levels of AKT, MEK, and S6 kinases at concentrations up to 10 μM. RKI-1447 is also highly selective in inhibiting Rock-mediated cytoskeletal recombination. RKI-1447 inhibits breast cancer cell migration, invasion and anchor-independent tumor growth [1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.06mL

0.61mL

0.31mL

15.32mL

3.06mL

1.53mL

30.64mL

6.13mL

3.06mL
参考文献

[1]Patel RA, et al. RKI-1447 is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activities in breast cancer. Cancer Res. 2012 Oct 1;72(19):5025-34.