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14-Deoxy-11,12-didehydroandrographolide

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Chemical Structure| 42895-58-9 同义名 : 14-dehydro Andrographolide;AP10;deAND
CAS号 : 42895-58-9
货号 : A316469
分子式 : C20H28O4
纯度 : 99+%
分子量 : 332.434
MDL号 : MFCD07778081
存储条件：

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(315.85 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

DMF: 100 mg/mL(300.81 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 14-Deoxy-11,12-didehydroandrographolide, herbs of Andrographis paniculata (Burm. f.) Nees, may cause autophagic morphology in the cells, shows more potent cytotoxicity against human promonocytic leukemia (THP-1) cells than adherent cancer cell lines, retains the anti-inflammatory activities of 2 for asthma probably through the inhibition of NF-κB and ameliorates astrocytic pro-inflammatory reactions and prevented PC12 cell death with different efficacies.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.01mL

0.60mL

0.30mL

15.04mL

3.01mL

1.50mL

30.08mL

6.02mL

3.01mL
参考文献

[1]Raghavan R, Cheriyamundath S, Madassery J. 14-Deoxy-11,12-didehydroandrographolide inhibits proliferation and induces GSH-dependent cell death of human promonocytic leukemic cells. J Nat Med. 2014 Apr;68(2):387-94.

[2]Tan ML, Tan HK, et al. Identification of genes involved in the regulation of 14-deoxy-11,12-didehydroandrographolide-induced toxicity in T-47D mammary cells. Food Chem Toxicol. 2012 Feb;50(2):431-44.