β-Nicotinamide mononucleotide

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Chemical Structure| 1094-61-7 同义名 : 烟酰胺核苷酸 (NMN) ;β-NM;NMN;Nicotinamide Mononucleotide;β-NMN
CAS号 : 1094-61-7
货号 : A315149
分子式 : C11H15N2O8P
纯度 : 97%
分子量 : 334.219
MDL号 : MFCD00038748
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

H2O: 85 mg/mL(254.32 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 β-Nicotinamide mononucleotide, a nicotinamide phosphoribosyltransferase product and vital NAD+ precursor, exhibits pharmacological benefits in cellular biochemistry, cardioprotection, diabetes, Alzheimer's, and obesity complications[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.99mL

0.60mL

0.30mL

14.96mL

2.99mL

1.50mL

29.92mL

5.98mL

2.99mL
参考文献

[1]Poddar SK, et al. Nicotinamide Mononucleotide: Exploration of Diverse Therapeutic Applications of a Potential Molecule. Biomolecules. 2019;9(1):34. Published 2019 Jan 21.

[2]Lv H, et al. NAD+ Metabolism Maintains Inducible PD-L1 Expression to Drive Tumor Immune Evasion [published online ahead of print, 2020 Nov 3]. Cell Metab. 2020;S1550-4131(20)30554-4.

[3]Li J, et al. p53 prevents doxorubicin cardiotoxicity independently of its prototypical tumor suppressor activities. Proc Natl Acad Sci U S A. 2019;116(39):19626-19634.

[4]Yoshino J, et al Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice. Cell Metab. 2011;14(4):528-536.