Zatebradine

产品说明书

Print
Chemical Structure| 85175-67-3 同义名 : UL-FS-49CL free base;UL-FS-49 free base
CAS号 : 85175-67-3
货号 : A313061
分子式 : C26H36N2O5
纯度 : 98%
分子量 : 456.575
MDL号 : MFCD00867014
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(109.51 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

无水乙醇: 100 mg/mL(219.02 mM)，配合低频超声助溶，注意：无水乙醇开封后，易挥发，也会吸收空气中的水分，导致溶解能力下降，请避免使用开封较久的乙醇
动物实验配方：
生物活性
描述 Zatebradine is a potent HCN channels antagonist, which decreased the heartbeat in a reversible manner, with 92% inhibition of the hHCN1-mediated current at 10 uM.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.19mL

0.44mL

0.22mL

10.95mL

2.19mL

1.10mL

21.90mL

4.38mL

2.19mL
参考文献

[1]Matt L, Michalakis S, et al. HCN2 channels in local inhibitory interneurons constrain LTP in the hippocampal direct perforant path. Cell Mol Life Sci. 2011 Jan;68(1):125-37.

[2]Gill CH, Randall A, et al. Characterization of the human HCN1 channel and its inhibition by capsazepine. Br J Pharmacol. 2004 Oct;143(3):411-21.